Epitalon (Epithalon) Testing
MW: 390.35 g/molHalf-life: Minutes in plasma; biological effects persist via gene expression changes.
Khavinson tetrapeptide based on natural epithalamin; telomerase research.
Mechanism of action
Synthetic tetrapeptide modeled on the natural pineal peptide epithalamin. Studied for effects on telomerase activity, melatonin regulation, and pineal-thymic axis function. The most-published of the Khavinson short-peptide bioregulators.
Sequence & structure
Ala-Glu-Asp-Gly (4 residues)
Very simple synthesis — which makes counterfeiting trivially easy. Identity verification by MS is essential for every lot.
Research areas
- ●Telomere length and cellular senescence
- ●Circadian rhythm and melatonin
- ●Anti-aging research (Khavinson group, Russia)
What we test on Epitalon (Epithalon)
Quantitative AAA, MS/MS sequence confirmation, RP-HPLC purity, endotoxin.
Standard Bioregulators Panel
- ✓MS/MS sequence confirmation
- ✓RP-HPLC purity
- ✓Quantitative AAA
Common impurities & failure modes
- Wrong peptide entirely
We have seen 'Epitalon' vials test as glutathione, as free amino acids, or as completely unrelated tripeptides. Mass-spec identity is non-negotiable.
- Mannitol-only fills
Some 'Epitalon' vials contain only the lyo bulking agent.
- Free amino acids
From hydrolysis of degraded material.
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